Adaptations in cholesterol metabolism upon T0901317 induced LXR activation. Adaptations in metabolic processes/components involved in hepatic cholesterol metabolism, normalized by the values of corresponding wild-type phenotype. The green dots represent the wild-type phenotype, whereas the blue and black dots represent the LXR activated phenotype. Solutions corresponding to an increased HDL-CE synthesis/uptake rate are colored blue, whereas solutions corresponding to a decreased HDL-CE synthesis/uptake rate are colored black. The ellipses were calculated by means of principal component analysis (PCA) and contain 95% of the corresponding solutions. ABCA1, ATP-binding cassette transporter 1; ABCG5, ATP-binding cassette transporter G5; SR-B1, scavenger receptor class B1.