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Figure 7 | BMC Systems Biology

Figure 7

From: Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation

Figure 7

No cross-talk from cAMP to cGMP pathway. (A) Bar plot of fold changes (mean of three measurements ± SEM) of different cyclic nucleotide levels for cAMP (white) and cGMP (black) with respect to basal cyclic nucleotide levels upon Forskolin stimulation (1-500 μM). Strong stimulation by Forskolin leads to high cAMP levels (A, D) by activating AC yet does not change low cGMP levels (C). Similarly, high doses of Cilostamide (50 μM), Milrinone (100 μM) and Iloprost (100 nM) elevate the cAMP level solely, leaving cGMP levels unaffected (B).

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