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Table 1 Evaluation of integrated feedback loops within the dynamic model.

From: Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation

Hypotheses Χ 2 N p Χ2/N AIC
H0 530.19 155 21 3.42 857.04
H1 185.52 155 22 1.2 514.395
H2 133.00 155 22 0.9 461.825
H3 129.08 155 23 0.8328 459.952
  1. Competing hypotheses: H0 - no integrated assumption of feedback loops; H1 - positive feedback of cAMP-dependent PKA to PDE3 (one additional parameter); H2 - negative feedback of elevated cAMP levels to AC (one additional parameter); H3 - both assumptions (H1, H2) are integrated within the mathematical model (two additional parameters). For each evaluated hypotheses the resulting χ2 -value, number of data points (N), number of estimated model parameters (p) and the Akaike information criterion (AIC) are listed.