Hypotheses

Χ
^{2}

N

p

Χ^{2}/N

AIC


H0

530.19

155

21

3.42

857.04

H1

185.52

155

22

1.2

514.395

H2

133.00

155

22

0.9

461.825

H3

129.08

155

23

0.8328

459.952

 Competing hypotheses: H0  no integrated assumption of feedback loops; H1  positive feedback of cAMPdependent PKA to PDE3 (one additional parameter); H2  negative feedback of elevated cAMP levels to AC (one additional parameter); H3  both assumptions (H1, H2) are integrated within the mathematical model (two additional parameters). For each evaluated hypotheses the resulting χ^{2} value, number of data points (N), number of estimated model parameters (p) and the Akaike information criterion (AIC) are listed.