|
Hypotheses
|
Χ
2
|
N
|
p
|
Χ2/N
|
AIC
|
|---|
|
H0
|
530.19
|
155
|
21
|
3.42
|
857.04
|
|
H1
|
185.52
|
155
|
22
|
1.2
|
514.395
|
|
H2
|
133.00
|
155
|
22
|
0.9
|
461.825
|
|
H3
|
129.08
|
155
|
23
|
0.8328
|
459.952
|
- Competing hypotheses: H0 - no integrated assumption of feedback loops; H1 - positive feedback of cAMP-dependent PKA to PDE3 (one additional parameter); H2 - negative feedback of elevated cAMP levels to AC (one additional parameter); H3 - both assumptions (H1, H2) are integrated within the mathematical model (two additional parameters). For each evaluated hypotheses the resulting χ2 -value, number of data points (N), number of estimated model parameters (p) and the Akaike information criterion (AIC) are listed.
