Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation

Table 1 Evaluation of integrated feedback loops within the dynamic model.

Hypotheses	Χ ²	N	p	Χ²/N	AIC
H0	530.19	155	21	3.42	857.04
H1	185.52	155	22	1.2	514.395
H2	133.00	155	22	0.9	461.825
H3	129.08	155	23	0.8328	459.952

Competing hypotheses: H0 - no integrated assumption of feedback loops; H1 - positive feedback of cAMP-dependent PKA to PDE3 (one additional parameter); H2 - negative feedback of elevated cAMP levels to AC (one additional parameter); H3 - both assumptions (H1, H2) are integrated within the mathematical model (two additional parameters). For each evaluated hypotheses the resulting χ² -value, number of data points (N), number of estimated model parameters (p) and the Akaike information criterion (AIC) are listed.

ISSN: 1752-0509