Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation

Table 2 Hypothesis testing and model selection.

Four competing hypotheses on feedback loop integration (see Table 2) are tested with regard to the given level of significance (0.05). For each scenario, the appropriate likelihood ratio test for nested model pairs was conducted (based on χ² -values of resulting model fit sequences). This reveals that the integration of both additional feedback constants is statistically relevant to explain all time series data on cAMP elevating drugs.

ISSN: 1752-0509