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Table 4 Modeled reactions and rates of basal cyclic nucleotide signaling.

From: Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation

Reaction

Rate

Basal AC influx of cAMP (r1):

Ï…1 = k11;

Basal GC influx of cGMP (r2):

Î¥2 = k12;

cAMP turnover via PDE2 (r3):

Ï… 3 = k 1 â‹… x 1 k 1 9 â‹… x 3 / k 2 + x 1 k 1 9 ;

cAMP turnover via PDE3 (r4):

υ4 = k3·x4·x1/(k4+x1);

cGMP turnover via PDE2 (r5):

υ5 = k5·x3·x2/(k6+x2);

cGMP turnover via PDE3 (r6):

υ6 = k7·x4·x2/(k8+x2);

cGMP turnover via PDE5 (r7):

υ7 = k9·x5·x2/(k10+x2);

(De)activation of PDE (r8- r13):

υ8 = k14·x6;

 

υ9 = k13·x3;

 

υ10 = k16·x7;

 

υ11 = k15·x4;

 

υ12 = k18·x8;

 

υ13 = k17·x5;

  1. Itemized modeled reactions r and rates Ï… describing the basal cyclic nucleotide signaling (see Appendix).