Figure 1

The HD and HO mediator networks and their subnetworks. Red, blue and yellow proteins are involved in three diseases (H: heart diseases, D: diabetes, O: obesity). Pink proteins mediate indirect effects between the red and the blue ones, while orange proteins mediate between the red and the yellow ones. Black proteins mediate between both pairs. White proteins are the non-mediator neighbours of the mediator proteins. We analyzed five networks: the HD mediator network (pink and black nodes with their white neighbours), the HO mediator network (orange and black nodes with their white neighbours), the total mediator network (pink, orange and black nodes with their white neighbours), the subnetwork of interactions among HD mediators (pink and black nodes) and the subnetwork of interactions among HO mediators (orange and black nodes).