Inferring pleiotropy by network analysis: linked diseases in the human PPI network

Nguyen, Thanh-Phuong; Liu, Wei-chung; Jordán, Ferenc

doi:10.1186/1752-0509-5-179

BMC Systems Biology

Table 3 Centrality ranks for the HD network.

From: Inferring pleiotropy by network analysis: linked diseases in the human PPI network

	nD		nCC		nBC		TI³		TO³_0.01		TO³_0.005
P62993	31.11	P62993	46.54	P62993	37.39	P62993	277.53	P62993	8066	P12931	20642
P63104	19.80	P12931	44.47	P63104	26.06	P63104	204.08	P63104	7107	P62993	19760
P06241	16.21	P22681	44.31	P12931	13.57	P06241	117.74	P12931	6893	P06241	19595
P12931	14.67	P00533	43.76	P17252	13.52	P12931	100.73	P06241	5541	P63104	18434
P17252	10.32	P06241	42.78	P49407	13.33	P49407	100.05	P17252	4025	P49407	16818
P49407	10.32	Q13813	42.67	P06241	12.97	P62736	95.47	P28482	2338	P62736	16177
P62736	9.81	P00519	42.01	P62736	11.69	P17252	90.13	P07948	2104	P17252	15588
P28482	8.97	P21333	41.75	P02768	10.94	P02768	86.69	P62736	1875	P28482	13598
P27361	7.43	P63104	41.74	P28482	9.30	P28482	66.61	P27361	1800	P22681	13337
P02768	7.19	P17252	41.69	P22681	5.71	P27361	52.43	P49407	1661	P07948	12088
P22681	5.42	P07355	41.48	P27361	5.35	Q03135	36.93	P22681	1634	P27361	9436
P07948	5.37	P61978	41.45	Q03135	4.67	P22681	36.86	P51681	1280	Q03135	9271
Q03135	4.58	P28482	41.39	P07948	3.38	P07948	35.10	P05129	955	P41240	7227
P41240	2.80	Q02156	40.82	P09471	2.25	Q99962	18.32	P09471	925	P05129	3574
P05129	2.43	P29353	40.77	Q99962	2.08	P05106	18.32	O15303	875	P05106	3532
P05106	2.38	P07900	40.70	P05106	2.02	P09471	18.02	O15492	875	P98082	1867
Q99962	2.01	P62988	40.68	P41240	1.44	P05129	17.42	O15539	875	P51681	1828
P09471	1.54	O14939	40.64	P00533	0.97	P41240	15.68	O15552	875	Q99962	1730
P13500	1.03	P43405	40.52	Q9UBS5	0.89	P48745	6.64	O43566	875	P18031	1574
O14788	0.79	Q06124	40.51	P18545	0.84	P13500	6.11	O43665	875	P00533	1521
P80098	0.79	Q07889	40.51	P13500	0.84	P80098	5.16	O76081	875	O15492	1504
P48745	0.61	P06396	40.29	P05129	0.82	P54646	5.08	P04899	875	P04004	1471
P00533	0.51	P56945	40.28	P06396	0.80	O14788	4.81	P08913	875	P49757	1471
P80075	0.51	P06213	40.19	P48745	0.76	P80075	2.53	P16473	875	P16284	1440
P54646	0.47	O43707	40.16	P80098	0.69	Q99616	2.42	P18545	875	P29353	1440
Q99616	0.47	Q05655	40.06	P61981	0.69	P00533	2.14	P18825	875	Q05397	1440
P29353	0.42	P49407	40.01	P11532	0.67	P29353	1.58	P30542	875	Q99704	1440
P06213	0.37	Q15746	40.00	O14788	0.64	P17302	1.51	P32302	875	P31751	1308
P17302	0.37	P23528	39.93	Q92616	0.62	P43405	1.44	P34998	875	P02751	1297
P43405	0.37	Q00839	39.93	P02751	0.59	P06213	1.43	P35372	875	P06756	1297

The rank of the most central 30 nodes in the HD network, based on the six importance indices analyzed.

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ISSN: 1752-0509

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