TY - JOUR AU - Bordbar, Aarash AU - Feist, Adam M. AU - Usaite-Black, Renata AU - Woodcock, Joseph AU - Palsson, Bernhard O. AU - Famili, Iman PY - 2011 DA - 2011/10/31 TI - A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology JO - BMC Systems Biology SP - 180 VL - 5 IS - 1 AB - Genome-scale metabolic reconstructions provide a biologically meaningful mechanistic basis for the genotype-phenotype relationship. The global human metabolic network, termed Recon 1, has recently been reconstructed allowing the systems analysis of human metabolic physiology and pathology. Utilizing high-throughput data, Recon 1 has recently been tailored to different cells and tissues, including the liver, kidney, brain, and alveolar macrophage. These models have shown utility in the study of systems medicine. However, no integrated analysis between human tissues has been done. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-5-180 DO - 10.1186/1752-0509-5-180 ID - Bordbar2011 ER -