Figure 1

General properties and characteristics of individual cell-specific metabolic reconstructions. (A) We modeled three cell-specific metabolic networks of human tissues: hepatocyte from liver, myocyte from skeletal muscle, and adipocyte of adipose tissue. (B) The tissue specific properties are broken up into three main sections. The first describes the topological and knowledge base characteristics of the metabolic networks. The second shows the in vitro growth rate and the required non-glucose carbon amount to maintain that growth rate. This growth rate was used as a maintenance function to model biological turnover. The third section details the energy and oxidative capacities of the networks. Note that the growth rate was set as a constraint for these simulations. (C) The biomass maintenance functions for the three metabolic networks were built based on the individual dry cell weight compositions. The AM is primarily composed of lipids while the MM is of protein. The HM has a more balanced composition with protein, glycogen, and lipids being the major components.