Table 8 Subsystem classification for essential reactions predicted for all six E. coli strains under aerobic conditions (n = 282).
Subsystem | Number of essential genes | Percentage(%) |
|---|---|---|
Alternate Carbon Metabolism | 3 | 1.1 |
Amino Acid Metabolism | 151 | 53.5 |
Cell Envelope Biosynthesis | 41 | 14.5 |
Citric Acid Cycle | 4 | 1.4 |
Cofactor and Prosthetic Group Biosynthesis | 72 | 25.5 |
Folate Metabolism | 3 | 1.1 |
Glycerophospholipid Metabolism | 12 | 4.3 |
Inorganic Ion Transport and Metabolism | 7 | 2.5 |
Lipopolysaccharide Biosynthesis/Recycling | 11 | 3.9 |
Membrane Lipid Metabolism | 2 | 0.7 |
Murein Biosynthesis | 2 | 0.7 |
Nucleotide Salvage Pathway | 8 | 2.8 |
Purine and Pyrimidine Biosynthesis | 19 | 6.7 |
Transport, Inner Membrane | 3 | 1.1 |
Transport, Outer Membrane | 13 | 4.7 |
Unassigned | 1 | 0.4 |