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Table 8 Subsystem classification for essential reactions predicted for all six E. coli strains under aerobic conditions (n = 282).

From: The evolution of metabolic networks of E. coli

Subsystem Number of essential genes Percentage(%)
Alternate Carbon Metabolism 3 1.1
Amino Acid Metabolism 151 53.5
Cell Envelope Biosynthesis 41 14.5
Citric Acid Cycle 4 1.4
Cofactor and Prosthetic Group Biosynthesis 72 25.5
Folate Metabolism 3 1.1
Glycerophospholipid Metabolism 12 4.3
Inorganic Ion Transport and Metabolism 7 2.5
Lipopolysaccharide Biosynthesis/Recycling 11 3.9
Membrane Lipid Metabolism 2 0.7
Murein Biosynthesis 2 0.7
Nucleotide Salvage Pathway 8 2.8
Purine and Pyrimidine Biosynthesis 19 6.7
Transport, Inner Membrane 3 1.1
Transport, Outer Membrane 13 4.7
Unassigned 1 0.4