TY - JOUR AU - Schmeier, Sebastian AU - Schaefer, Ulf AU - Essack, Magbubah AU - Bajic, Vladimir B. PY - 2011 DA - 2011/11/03 TI - Network analysis of microRNAs and their regulation in human ovarian cancer JO - BMC Systems Biology SP - 183 VL - 5 IS - 1 AB - MicroRNAs (miRNAs) are small non-coding RNA molecules that repress the translation of messenger RNAs (mRNAs) or degrade mRNAs. These functions of miRNAs allow them to control key cellular processes such as development, differentiation and apoptosis, and they have also been implicated in several cancers such as leukaemia, lung, pancreatic and ovarian cancer (OC). Unfortunately, the specific machinery of miRNA regulation, involving transcription factors (TFs) and transcription co-factors (TcoFs), is not well understood. In the present study we focus on computationally deciphering the underlying network of miRNAs, their targets, and their control mechanisms that have an influence on OC development. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-5-183 DO - 10.1186/1752-0509-5-183 ID - Schmeier2011 ER -