Box plots of the parameters corresponding to the different responses types. (A) Box plots of parameter sets leading to a transient (green) or sustained (red) response. Parameters that differ are mainly k8, k10, k11, k13 (shuttling rate from cytoplasm to nucleus, formation/dissolution of the Smad dimers, and dephosphorylation of R-Smad), and k5, k6, k14, k15, k17, k18, k19 (all related to the strengh of the feedback). (B) Box plots of parameter sets leading to a transient (green) or oscillatory (blue) response. k16, k17, k19 (dynamics of the I-Smad mRNA and I-Smad protein) and k2 (binding of TGF-β to its receptor) are key determinants of the response kind. Ranges of the uniform sampling distributions, as stated in Table S1, are indicated by grey boxes.