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Figure 5 | BMC Systems Biology

Figure 5

From: Deciphering causal and statistical relations of molecular aberrations and gene expressions in NCI-60 cell lines

Figure 5

Gene expressions of two TF expression association modules. Top: From the top to bottom: expressions of putative regulators of the module (SMAD3, FOXD1, PLAU, BDNF, FOSL2, FOSL1, RBMS1) and expressions of passenger genes. Bottom: From the top to bottom: expressions of putative regulators of the module (ERG, ELK4, NFATC1, RFX3, POU5F1, ZNF350) and expressions of passenger genes. Regulators are ordered by hierarchical clustering with their aberration profiles, and their dendrogram are displayed on the left of the panel. Passengers are sorted by their average similarity to the driver aberration profile. The top row has the highest similarity. BR: breast cancers, CNS: brain tumors, CO: colorectal cancers, LE: leukemias, ME: melanomas, LC: lung cancers, OV: ovarian cancers, PR: prostate cancers, RE: renal cancers. Samples 1 and 5 are estrogen-positive breast cancers, and samples 2-4 are estrogen-negative breast cancers.

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BMC Systems Biology

ISSN: 1752-0509

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