Skip to main content

Table 2 False discovery rates of mRNA and microRNA association modules

From: Deciphering causal and statistical relations of molecular aberrations and gene expressions in NCI-60 cell lines

mRNA modules:

  

FDR evaluation

driver type

FDR

mean

intra CNV

0.0259

mean

inter CNV

0.0035

mean

mutation

0.3467

mean

methylation

0.4334

mean

microRNA

0.2248

mean

TF

0.2197

mean

all

0.2353

99%

intra CNV

0.0855

99%

inter CNV

0.0899

99%

mutation

0.4949

99%

methylation

0.6322

99%

microRNA

0.3109

99%

TF

0.2815

99%

all

0.3262

microRNA modules:

  

FDR evaluation

driver type

FDR

mean

intra CNV

NA

mean

inter CNV

0.0021

mean

mutation

0.2535

mean

methylation

0.4403

mean

microRNA

NA

mean

TF

0.2857

mean

all

0.2924

99%

intra CNV

NA

99%

inter CNV

0.0455

99%

mutation

0.3645

99%

methylation

0.6379

99%

microRNA

NA

99%

TF

0.3600

99%

all

0.3943

  1. Mean: using the expected number of false positives to evaluate FDR. 99%: using the 99 percentile of the number of false positives to evaluate FDR. Intra CNV: intra-segment CNV. Inter CNV: inter-segment CNV. TF: transcription factor expressions. All: the FDR over all associations.