Skip to main content

Table 3 Enrichment of driver/regulator binding motifs on passenger promoters of mRNA association modules

From: Deciphering causal and statistical relations of molecular aberrations and gene expressions in NCI-60 cell lines

index reg N 1 N 2 N 3 p-value
44 MITF 118 2023 23 0.0464
45 TBP 77 8009 56 5.3704 × 10-4
45 MYB 77 10684 65 0.0076
46 SREBF2 49 9755 36 0.1581
47 E2F3 31 8123 21 0.0989
47 NFYA 31 2170 3 0.8513
47 SRF 31 75 0 1.0
51 NFATC3 22 2170 5 0.2097
53 NFKB2 19 531 0 1.0
66 TP53 35 3576 16 0.0041
76 PAX8 61 5376 34 0.0014
78 HOXC13 19 5421 12 0.0164
79 PPARG 13 20 0 1.0
81 mir-96 121 636 11 0.0147
81 mir-106a 121 319 6 0.0463
81 mir-17 121 830 12 0.0379
81 mir-93 121 832 12 0.0385
81 mir-106 121 718 11 0.0323
82 mir-21 120 291 7 0.0093
83 SMAD3 338 10025 271 1.058 × 10-7
84 ERG 338 2231 67 0.0093
84 ELK4 338 2803 76 0.0518
84 NFATC1 338 10187 265 3.1517 × 10-5
84 RFX3 338 2751 75 0.0481
84 POU5F 338 379 18 0.0027
  1. Index: module index. Reg: the transcription factor or microRNA with putative targets. N1: number of passenger genes in a module. N2: total number of putative targets in human genes. N3: number of passenger genes containing the transcription factor binding motif. p-value: hyper-geometric p-value of enrichment. For modules with microRNAs as drivers, N2: number of putative targets of a microRNA. N3: number of passenger genes belonging to the putative targets of the microRNA.