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Table 1 The different models RNA interference models for the RNAi-induced mRNA degradation rate δ ( X s , X m ) and their corresponding parameters.

From: Modeling RNA interference in mammalian cells

Model 1
δ ( X m , X s ) = k 1 X s X m k1: Rate of mRNA-siRNA* complex formation
Model 2
δ ( X m , X s ) = k 2 X s h 2 X m k2: Rate of mRNA-siRNA* complex formation h2: Number of siRNA target sites
Model 3
δ ( X m , X s ) = c 3 k 3 h 3 X s c 3 + k 3 h 3 X m X m k3: Rate of mRNA-siRNA* complex formation c3: Cleavage and dissociation rate of mRNA-siRNA* h3: Number of siRNA target sites
Model 4
δ ( X m , X s ) = d 4 X s h 4 θ 4 h 4 + X s h 4 X m d4: Maximal degradation rate of the mRNA due to RNAi θ4: Michaelis-Menten like constant h4: Number of siRNA target sites