Table 1 The different models RNA interference models for the RNAi-induced mRNA degradation rate δ ( X _s , X _m ) and their corresponding parameters.

$\delta (X_m,X_s)=k_1{X}_s{X}_m$

k₁: Rate of mRNA-siRNA* complex formation

$\delta (X_m,X_s)=k_2{X}_s^{h_2}{X}_m$

k₂: Rate of mRNA-siRNA* complex formation

h₂: Number of siRNA target sites

$\delta (X_m,X_s)=\frac{c_3{k}_3{h}_3{X}_s}{c_3+k_3{h}_3{X}_m}{X}_m$

k₃: Rate of mRNA-siRNA* complex formation

c₃: Cleavage and dissociation rate of mRNA-siRNA*

h₃: Number of siRNA target sites

$\delta (X_m,X_s)=d_4\frac{X_s^{h_4}}{{\theta }_4^{h_4}+X_s^{h_4}}{X}_m$

d₄: Maximal degradation rate of the mRNA due to RNAi

θ₄: Michaelis-Menten like constant

h₄: Number of siRNA target sites