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Table 2 Numerical fitting results of the four models for in vitro experimental data for the EGFP protein and mRNA.

From: Modeling RNA interference in mammalian cells

   Experiment on EGFP mRNA levels  
  Fit Err. Pred. Err. Parameters   
Model 1 1.00 0.98 k1 = 1.38 × 10-4(pmol min)-1,   
Model 2 0.13 0.12 k2 = 5.00 × 10-3(pmolh 2min)-1, h2 = 0.126,  
Model 3 1 1 k3h3 = 1.40 × 10-4(pmol min)-1, c3/km = 1.33 × 103a.u.,  
Model 4 0.04 0.05 θ4 = 0.105 pmol, d4 = 8.1 × 10-3min-1, h4 = 4.47
   Experiment on EGFP protein levels  
  Fit Err. Pred. Err. Parameters   
Model 1 0.97 0.81 k1 = 9.90 × 10-5(pmol min)-1,   
Model 2 0.46 0.39 k2 = 1.10 × 10-3(pmolh 2min)-1, h2 = 0.456,  
Model 3 1 1 k3h3 = 1.20 × 10-4(pmol min)-1, c3/k m = 1.33 × 103a.u.,  
Model 4 0.21 0.12 θ4 = 12.9 pmol, d4 = 8.6 × 10-3min-1, h4 = 4.49
  1. The relative value of the error (Fit Error) and the relative value of the prediction error (Pred. Err.) for each model are given, together with the corresponding optimized values of its parameters. The unit of measurements are reported for the dimensional parameters. (a.u. stands for arbitrary units of concentration).