Top Canonical Pathway: Role of hypercytokinemia and hyperchemokinemia in influenza. A. Integrated Pathway Analysis (IPA) canonical pathway map of the most significant pathway enriched in the set of highly predicted genes (Table 3). Shown in yellow are the highly cross-predicted genes. B. Expression patterns of highly predicted genes in Calu-3 cells and macaques. Dashed blue lines (CXCL10, IL29) indicate an earlier response and red lines (IL6, CCL4) are later in the Calu-3 infection.