Skip to main content

Advertisement

Table 1 Functional similarity between in vitro and in vivo models of influenza infection.

From: Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems

Biological Process Enrichment Scorea
  Calu3-early Calu3-late Both-mid Mac-early Mac-late
muscle contraction/circulatory system process 0.16 1.39* 2.23 1.40 2.03
chemotaxis 0.18 2.62 5.01 11.07 6.16
response to virus/innate immune response 0.24 2.06 2.54 7.78 2.96
response to external stimulus/locomotion 0.29 2.03 2.83 6.31 2.43
muscle system process/smell perception 0.20 0.95 1.49 1.75 2.92
mRNA processing/translation 0.18 3.96 0.73 1.47 1.85
regulation of immune response 0.21 1.69 1.04 3.54 1.57
mitosis/cell cycle phase 0.24 1.90 0.78 1.54 2.69
cytokine production/secretion 0.19 1.73 0.80 1.98 1.05
cell adhesion/division/microtubule-based process 0.30 1.99 0.80 0.95 2.00
transcription reguln/protein degradation/anti-apoptosis 0.17 2.73 0.62 1.07 0.88
proteasomal protein catabolic process 0.23 3.34 0.69 0.98 0.93
regulation of leukocyte proliferation 0.18 1.09 0.73 3.68 1.46
  1. a The geometric mean enrichment score was calculated for each treatment cluster-GO group combination. Enrichment score >1.3 corresponds to p < 0.05.
  2. *bold type indicates statistically significant values