Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems

Table 1 Functional similarity between in vitro and in vivo models of influenza infection.

Biological Process	Enrichment Score^a
	Calu3-early	Calu3-late	Both-mid	Mac-early	Mac-late
muscle contraction/circulatory system process	0.16	1.39*	2.23	1.40	2.03
chemotaxis	0.18	2.62	5.01	11.07	6.16
response to virus/innate immune response	0.24	2.06	2.54	7.78	2.96
response to external stimulus/locomotion	0.29	2.03	2.83	6.31	2.43
muscle system process/smell perception	0.20	0.95	1.49	1.75	2.92
mRNA processing/translation	0.18	3.96	0.73	1.47	1.85
regulation of immune response	0.21	1.69	1.04	3.54	1.57
mitosis/cell cycle phase	0.24	1.90	0.78	1.54	2.69
cytokine production/secretion	0.19	1.73	0.80	1.98	1.05
cell adhesion/division/microtubule-based process	0.30	1.99	0.80	0.95	2.00
transcription reguln/protein degradation/anti-apoptosis	0.17	2.73	0.62	1.07	0.88
proteasomal protein catabolic process	0.23	3.34	0.69	0.98	0.93
regulation of leukocyte proliferation	0.18	1.09	0.73	3.68	1.46

^a The geometric mean enrichment score was calculated for each treatment cluster-GO group combination. Enrichment score >1.3 corresponds to p < 0.05.
*bold type indicates statistically significant values

ISSN: 1752-0509