Table 3 Genes exhibiting consistent relationships with inferred regulatory influences between the Calu-3 model, macaque, and mouse response data.

ABI3

NM_016428

ABI gene family, member 3

0.35

MXD1

NM_002357

MAX dimerization protein 1

0.35

0.53

ALOX5

NM_000698

arachidonate 5-lipoxygenase

0.36

COL4A3

NM_000091

collagen, type IV, alpha 3 (Goodpasture antigen)

0.36

C1QTNF3

NM_181435

C1q and tumor necrosis factor related protein 3

0.38

CH25H

NM_003956

cholesterol 25-hydroxylase

0.38

0.86

FOS

NM_005252

v-fos FBJ murine osteosarcoma viral oncogene homolog

0.39

TNFSF13B

NM_006573

tumor necrosis factor (ligand) superfamily, member 13b

0.40

IL1R2

NM_004633

interleukin 1 receptor, type II

0.40

0.88

CD86

NM_006889

CD86 molecule

0.40

0.87

TNFAIP3

NM_006290

tumor necrosis factor, alpha-induced protein 3

0.41

0.70

ASCL2

NM_005170

achaete-scute complex homolog 2 (Drosophila)

0.41

IRX4

NM_016358

iroquois homeobox 4

0.41

BATF2

NM_138456

basic leucine zipper transcription factor, ATF-like 2

0.41

0.88

SCNN1G

X87160

sodium channel, nonvoltage-gated 1, gamma

0.42

PARP11

NM_020367

poly (ADP-ribose) polymerase family, member 11

0.42

0.83

CMTM2

NM_144673

CKLF-like MARVEL transmembrane domain containing 2

0.42

ADM

NM_001124

Adrenomedullin

0.43

0.77

PRSS12

NM_003619

protease, serine, 12 (neurotrypsin, motopsin)

0.44

USP18

NM_017414

ubiquitin specific peptidase 18

0.48

0.94

PI3

NM_002638

peptidase inhibitor 3, skin-derived (SKALP)

0.48

IL29

NM_172140

interleukin 29 (interferon, lambda 1)

0.54

UPP1

NM_181597

uridine phosphorylase 1

0.57

0.84

INDO

NM_002164

indoleamine-pyrrole 2,3 dioxygenase

0.58

0.90

LDHC

NM_002301

lactate dehydrogenase C

0.58

CXCL10

NM_001565

chemokine (C-X-C motif) ligand 10

0.58

0.96

RND1

NM_014470

Rho family GTPase 1

0.59

0.85

IFIT2

NM_001547

interferon-induced protein with tetratricopeptide repeats 2

0.60

0.97

IFIT1

NM_001548

interferon-induced protein with tetratricopeptide repeats 1

0.62

0.96

IFIT3

NM_001549

interferon-induced protein with tetratricopeptide repeats 3

0.64

0.97

ATF3

NM_004024

activating transcription factor 3

0.66

0.86

OASL

NM_003733

2'-5'-oligoadenylate synthetase-like

0.67

CCL4

NM_002984

chemokine (C-C motif) ligand 4

0.67

0.92

JUNB

NM_002229

jun B proto-oncogene

0.68

0.66

MX2

NM_002463

myxovirus (influenza virus) resistance 2

0.69

0.90

XAF1

NM_017523

XIAP associated factor-1

0.70

IL6

NM_000600

interleukin 6 (interferon, beta 2)

0.71

0.92

RSAD2

NM_080657

radical S-adenosyl methionine domain containing 2

0.89

0.85

OAS2

NM_016817

2'-5'-oligoadenylate synthetase 2, 69/71kDa

0.92

0.84