Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems

Table 4 Top inferred regulatory influences for highly cross-predicted genes.

	Predicted Regulatory Influence^a
Gene Symbol	GTF2B	ATF4	IFI44	IFNGR2	FOXE1	BRF1	ELF1	ELF2	IRF2
MXD1	-	+				-	+		-
C1QTNF3	+		-	-	-
CH25H	-	+				-	+		-
FOS	-			+					-
TNFSF13B			+	+
CD86	-	+				-	+		-
TNFAIP3	-	+				-	+		-
ASCL2			+	+
IRX4			+	+
BATF2			+	+
PARP11	-	-	+			+	+
CMTM2			+	+
ADM				-					+
USP18			+	+
PI3	-	-			+			-
IL29	-	-	+		+	+	-	-
UPP1	-	-			+			-
INDO	-	-	+
LDHC	-	-			+			-
CXCL10	-	-	+
RND1	-			+					-
IFIT2	-	-	+		+	+		-
IFIT1	-	-			+			-
IFIT3	-	-			+			-
OASL	-	-	+
CCL4	-			+					-
MX2	-	-	+
XAF1	-	-	+
IL6	-			+					-
RSAD2	-	-	+	+		-
OAS2	-	-	+	+		-
*Count*	29	23	20	17	12	11	10	11	10
*Trend*	-	-	+	+	+	-	+	-	-

^a "+" indicates positive and "-" negative regulation. Genes that are only regulated by one of these regulators are not shown.

ISSN: 1752-0509