Figure 10

Effect of receptor density on tumor cells. The fold-change in free VEGF concentration following anti-VEGF treatment is predicted as a function of VEGFR1, VEGFR2, and neuropilin (NRP) expression. In all simulations, NRP1 = NRP2. A, NRP = 0 molecules/tumor cell. B, NRP = 5,000 molecules/tumor cell. C, NRP = 10,000 molecules/tumor cell. D, NRP = 15,000 molecules/tumor cell. E, NRP = 20,000 molecules/tumor cell. F, NRP = 39,500 molecules/tumor cell. The white circle indicates receptor densities used in the current model: VEGFR1 = 1,100 molecules/tumor cell, VEGFR2 = 550 molecules/tumor cell, NRP1 = NRP2 = 39,500 molecules/tumor cell. G, NRP = 80,000 molecules/tumor cell. H, NRP = 100,000 molecules/tumor cell. A-H, The gray dotted line in all panels is the isocline for a fold-change of 1.