Effect of systemic properties permeability. The concentration of free VEGF in the body following anti-VEGF treatment is predicted for various parameter values. A, Microvascular permeability to VEGF between the normal tissue and blood. B, Microvascular permeability to VEGF between the tumor and blood. C, Lymphatic flow from tumor to blood. From top to bottom: normal tissue (subscript N), blood (subscript B), and tumor (subscript T). Bold in the legend indicates parameter value used in the current model.