Effect of anti-VEGF properties. The concentration of free VEGF in the body following anti-VEGF treatment is predicted as properties of the anti-VEGF are varied. A, Effect of microvascular permeability to anti-VEGF between the normal tissue and blood. B, Effect of microvascular permeability to anti-VEGF between the tumor and blood. C, Effect of clearance rate of anti-VEGF and VEGF/anti-VEGF complex. D, Effect of anti-VEGF binding affinity for VEGF. From top to bottom: normal tissue, blood, and tumor. Bold in the legend indicates parameter value used in the current model.