Figure 2

Centrality signature of the 22 highly central proteins. (a) Central proteins display highest average values (μ) for all the 6 normalized centralities (σ represents standard deviation): D - μ = 0.333, σ = 0.256; EC - μ = 0.418, σ = 0.347; TI1 - μ = 0.256, σ = 0.255; TI4 - μ = 0.271, σ = 0.247; B - μ = 0.286, σ = 0.243; C - μ = 0.881, σ = 0.074. (b) The remaining 1,635 proteins have average (normalized) centralities well below 0.1, except for closeness: D - μ = 0.010, σ = 0.019; EC - μ = 0.043, σ = 0.066; TI1 - μ = 0.002, σ = 0.011; TI4 - μ = 0.008, σ = 0.012; B - μ = 0.004, σ = 0.013; C - μ = 0.677, σ = 0.084. Highest scoring estimated for closeness can be explained by the short average distance between pairs of proteins in the complete network (4.182 steps).