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Figure 2 | BMC Systems Biology

Figure 2

From: Individualized therapy of HHT driven by network analysis of metabolomic profiles

Figure 2

Metabolites that were relatively increased in non-HHT individuals but decreased in the HHT patient (red arrows) included alanine, glycine, lysine, serine, tyrosine, glutamine, and creatinine. Metabolites that were relatively increased in the HHT patient (black arrows) included 3-hydroxybutyrate and acetate. Following treatment with bevacizumab, the HHT patient's profile (bottom panel) reversed the trend on the above metabolites, and developed a more 'normal' profile. Metabolite names: 1: 3-Hydroxybutyrate, 2: Acetate, 3: Acetone, 4: Alanine, 5: Arginine, 6: Asparagine, 7: Citrate, 8: Creatinine, 9: Formate, 10: Glucose, 11: Glutamate, 12: Glutamine, 13: Glycerol, 14: Glycine, 15: Glycolate, 16: Isoleucine, 17: Lactate, 18: Leucine, 19: Lysine, 20: Methanol, 21: Methionine, 22: Phenylalanine, 23: Pyruvate, 24: Serine, 25: Succinate, 26: Taurine, 27: Threonine, 28: Tyrosine, 29: Valine, 30: sn-Glycero-3-phosphocholine.

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