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Figure 11 | BMC Systems Biology

Figure 11

From: Stochastic adaptation and fold-change detection: from single-cell to population behavior

Figure 11

Two-state protein model with kinases and phosphatases as discrete mediators. (A-E) Single and (F-J) mean over a population of 50 cells, with initial concentration D(0) = 0.1 μM. Subfigures correspond to different levels of the signal A, in this case the kinase: (A, F) F i = 0.01, (B, G) F i = 0.1, (C, H) F i = 1, (D, I) F i = 10, and (E, J) F i = 100. Trajectories portray SSA simulations (blue), and input kinase signal (red). The following parameter values were used: k s = 0.05 , k f = 1 , k r = 0.1 , d P = 0.01 , d P m = 10 , k a 1 = 10 3 , k a 2 = k a 3 = k d 1 = k d 2 = k d 3 = 10 .

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