Figure 2From: Interactions among oscillatory pathways in NF-kappa B signalingThe deterministic, two-loop model of [19]. Proteins are shown as coloured ovals, while mRNA's are shown round-cornered rectangles. In addition to the direct negative feedback through which nuclear NF-κ B leads to the production of Iκ Bα, and thus to its own inactivation, the model also includes an indirect negative feedback mediated by A20's influence on the signal transduction machinery.Back to article page