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Figure 2 | BMC Systems Biology

Figure 2

From: Interactions among oscillatory pathways in NF-kappa B signaling

Figure 2

The deterministic, two-loop model of [19]. Proteins are shown as coloured ovals, while mRNA's are shown round-cornered rectangles. In addition to the direct negative feedback through which nuclear NF-κ B leads to the production of Iκ Bα, and thus to its own inactivation, the model also includes an indirect negative feedback mediated by A20's influence on the signal transduction machinery.

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