-Lipid A (KLA) stimulated sphingolipid metabolism pathway. The numbers above (or near) the arrows are reaction numbers (Table 1). The default degradation reactions are not labeled. Metabolites and enzymes are represented as rectangular boxes with round corner and rectangular boxes, respectively. The measured and unmeasured metabolites that are and are not present in detectable amounts are differentiated by thick and thin borders, respectively. For full name of metabolites, see the list of abbreviations, presented at the end of the manuscript.