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Table 1 The estimated values of the rate parameters in the model of sphingolipid metabolism.

From: Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism

No. Reactions Parameter
Names
Values
1 DHSph + CoA16 + CerS6 → C16 DHCer kf1 1.30E+01 ± 1.01E-02
2 DHSph + CoA16 → C16 DHCer kf2 5.62E-02 ± 1.30E-02
3 C16 DHCer → kf3 1.11E-03 ± 3.20E-03
4 DHSph + Sphk1 → DHSph1P kf4 1.49E-04 ± 1.11E-03
5 DHSph + Sphk2 → DHSph1P kf5 1.61E-02 ± 8.38E-04
6 DHSph1P → kf6 5.28E-01 ± 1.83E-02
7 C16 DHCer + Ugcg → C16 DHGlcCer kf7 1.81E-02 ± 2.71E-03
8 C16 DHGlcCer → kf8 2.99E-01 ± 3.25E-02
9 C16 DHCer + Sms1 + C16 GPCho ←→ kf9 1.15E-01 ± 6.85E-03
  C16 DHSM + Sms1 + C16 DG kb9 1.7176 ± 5.47E-03
10 C16 DHCer + Sms2 + C16 GPCho ←→ kf10 3.88E-01 ± 1.02E-02
  C16 DHSM + Sms2 + C16 DG kb10 8.63E-01 ± 1.23E-02
11 C16 DHSM + Smpd1 → C16 DHCer kf11 1.07E-01 ± 5.62E-03
12 C16 DHSM → kf12 2.49E-02 ± 3.01E-03
13 C16 DHCer + Cerk → C16 DHCerP kf13 5.00E-05 ± 7.20E-06
14 C16 DHCerP → kf14 8.25E-02 ± 6.57E-03
15 C16 DHCer + Degs1 → C16 Cer kf15 9.07E-03 ± 9.56E-03
16 C16 DHCer → C16 Cer kf16 8.03E-01 ± 1.39E-02
17 C16 Cer + Cerk → C16 CerP kf17 1.29E-04 ± 7.64E-06
18 C16 CerP → kf18 1.12E-01 ± 4.05E-03
19 C16 Cer + Sms1 + C16 GPCho ←→ kf19 6.50E-02 ± 3.13E-02
  C16 SM + Sms1 + C16 DG kb19 4.72E-02 ± 8.67E-03
20 C16 Cer + Sms2 + C16 GPCho ←→ kf20 4.48E-01 ± 2.50E-02
  C16 SM + Sms2 + C16 DG kb20 1.3343 ± 2.52E-02
21 C16 SM + Smpd1 → C16 Cer kf21 1.91E-05 ± 1.98E-02
22 C16 SM → kf22 9.79E-03 ± 1.28E-03
23 C16 Cer → kf23 0.00E+00 ± 2.55E-03
24 C16 Cer + Ugcg → C16 GlcCer kf24 2.39E-02 ± 3.05E-03
25 C16 GlcCer → kf25 4.58E-03 ± 3.43E-03
  1. Microarray data was used for protein concentration.
  2. X → means default degradation of the metabolite X.
  3. Unit of first order reaction is 1/hr.
  4. Unit of second order reaction is 1/hr when it involves protein as a modifier as we have used fold change data with respect to control for these variables.
  5. Unit of third order reaction is μg DNA/(pmol * hr) when it involves protein as a modifier.
  6. Unit of third order reaction is μg DNA/(Ratio Int * hr) when it involves DG and protein as modifiers.