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Table 1 The estimated values of the rate parameters in the model of sphingolipid metabolism.

From: Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism

No.

Reactions

Parameter

Names

Values

1

DHSph + CoA16 + CerS6 → C16 DHCer

kf1

1.30E+01 ± 1.01E-02

2

DHSph + CoA16 → C16 DHCer

kf2

5.62E-02 ± 1.30E-02

3

C16 DHCer →

kf3

1.11E-03 ± 3.20E-03

4

DHSph + Sphk1 → DHSph1P

kf4

1.49E-04 ± 1.11E-03

5

DHSph + Sphk2 → DHSph1P

kf5

1.61E-02 ± 8.38E-04

6

DHSph1P →

kf6

5.28E-01 ± 1.83E-02

7

C16 DHCer + Ugcg → C16 DHGlcCer

kf7

1.81E-02 ± 2.71E-03

8

C16 DHGlcCer →

kf8

2.99E-01 ± 3.25E-02

9

C16 DHCer + Sms1 + C16 GPCho ←→

kf9

1.15E-01 ± 6.85E-03

 

C16 DHSM + Sms1 + C16 DG

kb9

1.7176 ± 5.47E-03

10

C16 DHCer + Sms2 + C16 GPCho ←→

kf10

3.88E-01 ± 1.02E-02

 

C16 DHSM + Sms2 + C16 DG

kb10

8.63E-01 ± 1.23E-02

11

C16 DHSM + Smpd1 → C16 DHCer

kf11

1.07E-01 ± 5.62E-03

12

C16 DHSM →

kf12

2.49E-02 ± 3.01E-03

13

C16 DHCer + Cerk → C16 DHCerP

kf13

5.00E-05 ± 7.20E-06

14

C16 DHCerP →

kf14

8.25E-02 ± 6.57E-03

15

C16 DHCer + Degs1 → C16 Cer

kf15

9.07E-03 ± 9.56E-03

16

C16 DHCer → C16 Cer

kf16

8.03E-01 ± 1.39E-02

17

C16 Cer + Cerk → C16 CerP

kf17

1.29E-04 ± 7.64E-06

18

C16 CerP →

kf18

1.12E-01 ± 4.05E-03

19

C16 Cer + Sms1 + C16 GPCho ←→

kf19

6.50E-02 ± 3.13E-02

 

C16 SM + Sms1 + C16 DG

kb19

4.72E-02 ± 8.67E-03

20

C16 Cer + Sms2 + C16 GPCho ←→

kf20

4.48E-01 ± 2.50E-02

 

C16 SM + Sms2 + C16 DG

kb20

1.3343 ± 2.52E-02

21

C16 SM + Smpd1 → C16 Cer

kf21

1.91E-05 ± 1.98E-02

22

C16 SM →

kf22

9.79E-03 ± 1.28E-03

23

C16 Cer →

kf23

0.00E+00 ± 2.55E-03

24

C16 Cer + Ugcg → C16 GlcCer

kf24

2.39E-02 ± 3.05E-03

25

C16 GlcCer →

kf25

4.58E-03 ± 3.43E-03

  1. Microarray data was used for protein concentration.
  2. X → means default degradation of the metabolite X.
  3. Unit of first order reaction is 1/hr.
  4. Unit of second order reaction is 1/hr when it involves protein as a modifier as we have used fold change data with respect to control for these variables.
  5. Unit of third order reaction is μg DNA/(pmol * hr) when it involves protein as a modifier.
  6. Unit of third order reaction is μg DNA/(Ratio Int * hr) when it involves DG and protein as modifiers.