Metabolic reconstruction of the archaeon methanogen Methanosarcina Acetivorans

BMC Systems Biology

Table 1 In vivo gene deletion data used evaluate and improve i VS941's predictive capabilities (Citations are indicated in square brackets).

	Substrate
Gene deletions	acetate	carbon monoxide	methanol	monomethylamine	dimethylamine	trimethylamine
ackR	NGNG	GNG[51]	-	-	-	-
ATP synthase	NGNG[52]	-	GNG[52]	-	-	-
DMTsD	GG[53]	GG[53]	GG[53]	-	-	GG[53]
mtsD+mtsF	GG[53]	GG[53]	GG[53]	-	-	GG[53]
mtsD+mtsH	GG[53]	GG[53]	GG[53]	-	-	GG[53]
mtsF	GG[53]	GG[53]	GG[53]	-	-	GG[53]
mtsH	GG[53]	GG[53]	GG[53]	-	-	GG[53]
mtsF+mtsH	GG[53]	GG[53]	GG[53]	-	-	GG[53]
lysK	-	-	GG[54]	-	GG[54]	GG[54]
lysS	-	-	GG[54]	GG[54]	GG[54]	GG[53]
MCR	NGNG[43]	GNG[43]	NGNG[43]	GNG[43]	GNG[43]	GNG[43]
mtaA1	-	-	NGNG[39]		-	-
mtaA1 + MT1	GNG[39]	-	-	-	-	-
mtaA2	-	-	GG[39]	-	-	-
mtaCB1	-	-	GG[55]	-	-	-
mtaCB1 + mtaCB2	-	-	GG[55]	-	-	-
mtaCB1 + mtaCB2 + mtaCB3	-	-	GNG[55]	-	-	-
mtaCB2	-	-	GG[55]	-	-	-
mtaCB3	-	-	GG[55]	-	-	-
mtbA	-	-	-	NGNG[39]	NGNG[39]	-
mtbA	-	-	-	-	-	GG[54]
ppylT	GG[56]	-	GG[56]	GNG[56]	GNG[56]	GNG[56]
ptaR	NGNG	GNG[51]	-	-	-	-
Rnf complex	GNG[57]	-	-	-	-	-

ISSN: 1752-0509