Figure 1From: Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivityReaction scheme for EGFR signal transduction pathway in H1299 cells. The reaction steps of the EGFR signaling pathway are labeled from 1 to 27. These numbers correspond to the biochemical reactions in Additional file 1, Table S1. Steps 4, 11, and 15-27 are described by Michaelis-Menten kinetics and the other reactions by mass action. The individual reaction equations, the estimated parameters, and the estimated ranges are explained in Additional file 1, Table S2-5. The inhibitory effects of Mig6 and gefitinib are indicated by red lines. E11: EGFR homodimer; ShcP: free phosphorylated Shc; E11P: phosphorylated EGFR homodimer; Raf1A: activated Raf1; MEKP: singly phosphorylated MEK; MEKPP: doubly phosphorylated MEK; ERKP: singly phosphorylated ERK; ERKPP: doubly phosphorylated ERK.Back to article page