WT model
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EGFR-WT model
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EGFR overexpression
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Increased EGFR initial concentration
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EGFR overexpression
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Increased EGFR initial concentration
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Slow rate for the forward reaction of EGFR phosphorylation (k3)
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L858R model A
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Mig6 overexpression
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Slow rate for the forward reaction of binding of phosphorylated EGFR to Cbl (k5)
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Slow rate for the forward reaction of binding of phosphorylated EGFR to GAP (k7)
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Slow rate for the forward reaction of binding of phosphorylated EGFR to Shc (k8)
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EGFR overexpression
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Increased EGFR initial concentration
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L858R model B
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Increased ubiquitin-dependent EGFR degradation
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Increased Cbl initial concentration
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