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Table 1 Differences in characteristics among the four H1299 models.

From: Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity

  Circumstances Model description
WT model ----- -----
EGFR-WT model EGFR overexpression Increased EGFR initial concentration
  EGFR overexpression Increased EGFR initial concentration
   Slow rate for the forward reaction of EGFR phosphorylation (k3)
L858R model A Mig6 overexpression Slow rate for the forward reaction of binding of phosphorylated EGFR to Cbl (k5)
   Slow rate for the forward reaction of binding of phosphorylated EGFR to GAP (k7)
   Slow rate for the forward reaction of binding of phosphorylated EGFR to Shc (k8)
  EGFR overexpression Increased EGFR initial concentration
L858R model B Increased ubiquitin-dependent EGFR degradation Increased Cbl initial concentration
  1. (comparison with WT model)
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BMC Systems Biology

ISSN: 1752-0509

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