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Table 1 Differences in characteristics among the four H1299 models.
| Circumstances | Model description | |
|---|---|---|
| WT model | ----- | ----- |
| EGFR-WT model | EGFR overexpression | Increased EGFR initial concentration |
| EGFR overexpression | Increased EGFR initial concentration | |
| Slow rate for the forward reaction of EGFR phosphorylation (k3) | ||
| L858R model A | Mig6 overexpression | Slow rate for the forward reaction of binding of phosphorylated EGFR to Cbl (k5) |
| Slow rate for the forward reaction of binding of phosphorylated EGFR to GAP (k7) | ||
| Slow rate for the forward reaction of binding of phosphorylated EGFR to Shc (k8) | ||
| EGFR overexpression | Increased EGFR initial concentration | |
| L858R model B | Increased ubiquitin-dependent EGFR degradation | Increased Cbl initial concentration |
