Table 1 Differences in characteristics among the four H1299 models.
| Â | Circumstances | Model description |
|---|---|---|
WT model | ----- | ----- |
EGFR-WT model | EGFR overexpression | Increased EGFR initial concentration |
| Â | EGFR overexpression | Increased EGFR initial concentration |
| Â | Â | Slow rate for the forward reaction of EGFR phosphorylation (k3) |
L858R model A | Mig6 overexpression | Slow rate for the forward reaction of binding of phosphorylated EGFR to Cbl (k5) |
| Â | Â | Slow rate for the forward reaction of binding of phosphorylated EGFR to GAP (k7) |
| Â | Â | Slow rate for the forward reaction of binding of phosphorylated EGFR to Shc (k8) |
| Â | EGFR overexpression | Increased EGFR initial concentration |
L858R model B | Increased ubiquitin-dependent EGFR degradation | Increased Cbl initial concentration |