Figure 8
From: A general framework for modeling growth and division of mammalian cells
Numbers of cycB/Cdk1 over two cell divisions. cycB and Cdk1 are induced and enhanced by E2F, B-Myb, and NF-Y. Cdk1 also has constitutive expression. cycB/Cdk1 accumulates during S phase but is phosphorylated and inactivated by Wee1. Loss of Wee1 and the presence of active Cdc25B (activated by cycA/Cdk1) begin the dephosphorylation and activation of cycB/Cdk1 and thus trigger the cascade between cycB/Cdk1 and constitutive Cdc25C. Active cycB/Cdk1 further activates Plk1, which promotes the translocation of cycB/Cdk1 to the nucleus, completing the G2/M transition.