Figure 3

Visualization of the first three model simplifications. Removed components are shown in gray. Red numbers indicate the iteration k of the work flow in which the reaction has been removed. Unidentifiable parameters are stated next to the respective reaction. In the first iteration the reactions containing kf7, kd7 and the species IFN_R_JAKPhos_2_STAT1cPhos have been removed. In the second iteration the dissociation reactions containing the parameters kd5, kd9, kd11, and kd24 have been removed. In the third iteration the model was simplified by deleting the species R and JAK and the corresponding dissociation and association reactions. A mathematical representation of the models created in each iteration is given in Additional file 1.