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Figure 4 | BMC Systems Biology

Figure 4

From: Convergence of Logic of Cellular Regulation in Different Premalignant Cells by an Information Theoretic Approach

Figure 4

An inversion in the expression level genes at two consecutive time points. An inversion in the expression level of one hundred genes at two consecutive points in time along the trajectory 1-5-7-8-10-12. Only a hundred values are shown for clarity but the same pattern recurs for all values of the gene index i. The change in the expression level, equation (2), is a sum over all patterns. The plot shows only the dominant, see Figure 3, term α = 1, between points 7, red online, and 8, blue online. Note the ln of the gene level changes by a factor of more than 5, exp(5) = 150. So the inversion is fairly extreme being by more than two orders of magnitude. As seen in Figure 3 there is a big change in the sign of λ α = 1(t T ) between T = 7 and 8.

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