Figure 6

Identification of the major and minor transcription patterns participating in the cellular transformation. Microarray analysis using to the information-theoretic approach reveals gene expression patterns underlying the transition between particular stages in the in vitro transformation model. Selected gene expression networks in each transcription pattern (α) are shown in the white boxes. The time points are colored according to their trajectories as also shown in Figure 1: blue, the common route before the branching; pale blue, the split generating the trajectory 1-5-6; purple, the split generating the trajectory 1-5-7-8-9; red, the split generating the trajectory 1-5-7-8-10-12, yellow the split generating the trajectory 1-5-7-8-10-11. We suggest that the main transcription pattern α = 1 in the trajectory 1-5-7-8-10-12 is the necessary condition in the transition from normal tissue all the way to cancer. The third transcription pattern α = 3 in the trajectory 1-5-7-8-10-12 completes the necessary expression networks of the transcription pattern α = 1 and insures the sufficient conditions for the tumor formation.