Comparison of different methods applied to the T cell receptor signaling network with NFκB as the output. (a) Importance values obtained by single-node deletion of original nodes. (b) Importance values obtained by single-node deletion of complementary nodes. (c) Prediction accuracy. Rectangles indicate the importance values or prediction accuracy obtained by the ESM measure, circles represent the simple path measure, diamonds denote the SigFlux measure, and triangles show the betweenness centrality measure.