Figure 1

Scatter plot between the SGA and GIM datasets. (A) Original double-mutant fitness measurements from the two screening approaches. (B) Interaction scores: custom-designed score from the SGA data and the median estimate for single-mutant effects with product scoring function in the GIM data. The dotted lines correspond to the extreme 3% level quantiles in the two datasets. The green and red points indicate the positive and negative interactions, respectively, as extracted from the BioGRID database (version 3.0.64, interactions extracted from the SGA and GIM datasets under study were excluded from the two interaction classes).