Figure 3

Rank scatter plot between the SGA and GIM datasets. (A) Interaction score rankings based on the fixed QMA setting for scoring positive interactions. The dotted lines indicate the extreme 3% quantiles in the two datasets. The green and red points indicate the positive and negative interactions, respectively, as extracted from the BioGRID database (version 3.0.64, interactions extracted from the SGA and GIM datasets under study were excluded from the interaction classes). (B) Enrichment p-values for the positive interactions (upper values, green colouring) and for the negative interactions (lower values, red colouring) in different regions of the scatter plot. Empty cells indicate that the enrichment p-value is larger than 0.99.