Diagram showing the structure of the boar spermatozoa capacitation network and the subcellular localization of nodes. The node size was proportional to the connection number and the node color gradient was dependent from the closeness centrality. This parameter is computed as: Cc(n) = 1/avg(L(n,m)), were L (n,m) is the length of the shortest path between two nodes n and m. The closeness centrality of each node ranges from 0 (red) to 1 (green) and it is a measure of how fast the information spreads from a given node to the other nodes. The actn polymerization node is indicated by the red arrow, its links by blue line. All the nodes were localized in their specific subcellular domain (Cerebral V.2).