Information theory-based semantic similarity (ITTS) for predicting function through interacting proteins. A. If Orthology value exceed a threshold, we considered the protein pair between 2 functional modules as real orthologs and transfer GO terms specifically between annotated protein one species (yellow) to un-annotated × M. genitalium protein (red). B. Calculate semantic similarity between this GO terms assigned and GO terms from annotated neighbouring proteins inside the M. genitalium functional module. C. Consider GO terms A with similarity above a threshold, then associate protein × with GO. Orange dotted lines indicate Semantic similarity calculations.