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Table 1 Parameter values used in simulations

From: Theoretical basis of the community effect in development

Parameter Reaction Parameter value (sec -1) t0.5(approx.)
α 1 Binding of transcriptional activator to promoter 1.93 × 10 -4 1 hr
α 2 Dissociation of transcriptional activator from promoter 3.47 × 10 -2 20 sec
β Transcription 1.16 × 10 -2 1 min
γ Translation 2.31 × 10 -2 30 sec
δ a , δ b , δ c , δ d Degradation/disappearance of proteins 3.47 × 10 -4 33 min
δ m Degradation of mRNA 1.16 × 10 -3 10 min
κ Exocytosis 3.85 × 10 -4 30 min
ε 'Communication' by extracellular factor 2.31 × 10 -6 or 5.78 × 10 -7 83 or 333 hrs
  1. Simulation parameters are all within biologically or biochemically relevant range, which usually spans orders of magnitude, such as the one for protein degradation rates. Where possible, we have referred to reaction rates that have been determined experimentally to choose parameter values for simulations (for example, [3945]). ε is an abstract parameter and its value for stochastic simulations was estimated and chosen so that a community effect could be realised in silico.