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Table 1 Results of leave-one-out cross-validation experiments on the small network.

From: DomainRBF: a Bayesian regression approach to the prioritization of candidate domains for complex diseases

  

Random Control (%)

Linkage Interval (%)

Genome-wide Scan(%)

  

R 2

BF

R 2

BF

R 2

BF

Precision

SG

26.11 (0.66)

26.56 (0.85)

21.69

23.79

6.29

5.25

 

DK

26.25 (0.63)

28.67 (0.72)

19.60

31.20

7.13

5.53

Mean Rank Ratio

SG

17.31 (0.11)

11.99 (0.05)

18.24

11.19

16.49

11.17

 

DK

17.82 (0.13)

10.75 (0.09)

19.09

9.73

17.03

9.91

AUC

SG

83.51 (0.10)

88.80 (0.05)

82.81

89.94

83.60

88.85

 

DK

83.01 (0.12)

90.04 (0.11)

81.95

90.18

83.06

90.11

  1. The small network indicates the domain-domain interaction network that is composed of the PDB part of the DOMINE database. R2 denotes the ordinary non-Bayesian linear regression approach (using R-square as scores for candidate domains). BF denotes the domainRBF approach (using Bayes factors as scores for candidate domains). SG denotes shortest path with Gaussian kernel. DK denotes diffusion kernel. Results for random controls are mean (standard deviation) of 10 validation runs.
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BMC Systems Biology

ISSN: 1752-0509

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