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Table 3 Effects of parameters based on leave-one-out cross-validation experiments.

From: DomainRBF: a Bayesian regression approach to the prioritization of candidate domains for complex diseases

Criteria σ 1 2 Random Control (%) Linkage Interval (%) Genome-wide Scan (%)
Precision 0.001 28.87 (0.70) 31.49 4.41
  0.01 29.02 (1.17) 31.77 4.78
  0.1 29.39 (0.60) 31.36 5.07
  1 28.67 (0.72) 31.20 5.53
  10 27.76 (0.62) 29.73 5.35
  100 28.59 (1.18) 28.16 5.35
Mean Rank Ratio 0.001 10.23 (0.07) 9.83 9.38
  0.01 10.25 (0.11) 9.98 9.41
  0.1 10.41 (0.07) 9.49 9.54
  1 10.75 (0.09) 9.73 9.91
  10 11.14 (0.10) 10.92 10.27
  100 12.08 (0.10) 11.95 11.24
AUC 0.001 90.58 (0.10) 90.14 90.55
  0.01 90.56 (0.14) 90.40 90.61
  0.1 90.40 (0.10) 90.22 90.40
  1 90.04 (0.11) 90.18 90.11
  10 89.69 (0.10) 89.23 89.86
  100 88.74 (0.14) 88.41 88.98
  1. The small domain-domain interaction network composed of the PDB part of the DOMINE database and the diffusion kernel are used to obtain the results. Results for random controls are mean (standard deviation) of 10 validation runs.