Skip to main content

Table 1 Goals of computational model to match with experimental observations.

From: Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis

VEGF Metric

Effect of a decrease in isoform length

Effect of VEGF cleavage

Level of Soluble VEGF

↑ [21]

↑ [7]

Level of Bound VEGF

↓ [24]

↓ [19] *

Level of Total VEGF

= [7] *

= [7, 19] *

Magnitude of soluble VEGF gradients

↓ [13]

↓ [17]

Spatial Range of soluble VEGF

↑ [12]

↑ [17]

  1. Note the concordance of the outcomes of decreased isoform length and VEGF cleavage.
  2. * hypothesized, or some supporting evidence, but no definitive experimental confirmation