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Table 1 Biomarkers score

From: Systems biological approach on neurological disorders: a novel molecular connectivity to aging and psychiatric diseases

Disease

Biomarkers (score)

Alzheimer's Disease

APLP2 (4), NEU2 (1.4), PCDH11X (0.5), SUMF1 (0.5), TOMM40 (0.5)

Amyotrophic Lateral Sclerosis

ALS2CR8 (0.5), DERL1 (0.5), FUS (1), HOPX (0.5), KIF1A (0.5), MOBKL2B(0.5), NIF3L1 (0.5), SCN7A (0.5), SEMA6A (1.4), SLC39A11(0.5), STRADB (0.5), SUSD1(0.5), UNC13A(0.5), ZFP64(0.5)

Angelman Syndrome

ARID4A (1.4), ARID4B (0.5), MKRN3 (1), NDNL2 (0.5), NIPA2 (0.5), PHLDA2 (0.5), SLC9A6(0.5), TSPAN32 (0.5), TSSC4 (0.5)

Asperger Syndrome

GPR172B (0.5)

Ataxia Telangiectasia

DDX10 (1), HEPACAM (1.4), TCL1A (0.5)

Canavan Disease

ASPA(0.5)

Dyslexia

ARFGEF1 (0.5), CCPG1 (0.5), PDGFC (0.5)

Epilepsy

TRAPPC10 (0.5)

Fatal Familial Insomnia

CD68 (0.5)

Friedreich Ataxia

ACO1 (0.5)

Huntington disease

AKAP8L (0.5), ARFIP2 (0.5)

Korsakoff Syndrome

TKTL1 (0.5)

Lambert-Eaton Myasthenic Syndrome

RAPSN (0.5), SOX1 (0.5)

Major Depressive Disorder

FKBP5 (1), PCLO (2)

Manic Depressive Psychosis

TRPM2(0.5)

Multiple Sclerosis

CSMD1 (0.5), FCGR1A (2), FCGR1B (2), FCGR2A (3.5), FCGR2B (5), FCGR2C (4.1), FCGR3A (4.1), FCGR3B (0.5), IFNB1 (0.5)

Multiple System Atropy

AGTPBP1 (0.5), EXTL3 (0.5)

Parkinson's Disease

CALB1(5), CSF1R (5), MT-CYB(0.5), CHAC1 (0.5), NPFF (0.5)

Pathologic gambling

DNER (3.5)

Restless Legs Syndrome

DMRT1 (0.5)

Schizophrenia

AP3B2(2), HMBS (0.5), SETD2(1.4), ST6GAL2(3.5)

Septo-Optic Dysplasia

LBX1 (1)

Stroke

NINJ2(0.5), PROZ (0.5)

von Hippel-Lindau Disease

TCHP (0.5)

  1. The biomarkers of 24 diseases were indicated along with their diagnostic score. The biomarkers that are shown to be specific to neurological and psychiatric diseases in comparison with GWAS database are indicated in bold.