Figure 3
Plots of crowding effects (equation 2) and TGF-β 1 activation function u T (equation 4). A: Crowding effects (k mem (t) in equation 2) contributed by myocytes, endothelial cells, and vascular smooth muscle cells. B: Crowding effects contributed by macrophages, fibroblasts, and collagen in the scar tissue. C: Total crowding effects imposed by the environment. D: TGF-β1 activation function, u T according to small scar size. Activation peak time is at day 2 post-MI with amplitude at 15 pg/μL/day.