Symbol | Biological meaning | Value | Units | Ref |
---|---|---|---|---|
dMΦ | Macrophage removal rate**(eqn 1) | 0.6 | day-1 | [29] |
ρMΦ | maximal macrophage density (eqn 2) | 2500 | cells/mm3 | [28] |
ρF | maximal fibroblast density(eqn 2) | 1250 | cells/mm3 | [28] |
ρC | maximal collagen density (eqn 2) | 3300 | μg/mm3 | [28] |
kF | Fibroblast growth rate* (eqn 3) | 0.924 | day-1 | [62] |
dF | Fibroblast apoptosis rate (eqn 3) | 0.12 | day-1 | [33] |
kMΦT | Macrophage TGF-β production rate (eqn 4) | 0.07 | pg/cell/day | [34] |
kFT | Fibroblast TGF-β production rate (eqn 4) | 0.004 | pg/cell/day | [35] |
dTβ | TGF-β degradation rate¥(eqn 4) | 15 | day-1 | [36] |
KMφM9 | Macrophage secretion MMP9 rate (eqn 5) | 3 | pg/cell/day | estimated |
dM9 | MMP-9 degradation rate(eqn 5) | 0.875 | day-1 | |
kon | Kinetic reaction speed (eqn 5) | 3 × 10-4 | 1/(μg/mm3)s-1 | |
koff | Kinetic reaction speed (eqn 5) | 4 × 10-4 | s-1 | |
konc | Kinetic reaction speed (eqn 6) | 0.004 | s-1 | |
kFC | Fibroblast collagen production rate (eqn 6) | 20 | μg/cell/day | [41] |