Parameter description | Symbols |
Prior Distribution (P1, P2)^{a} | Reference | Mean (Posterior Distribution) | Median (Posterior Distribution) | 95% Confidence Interval (Posterior Distribution) |
---|---|---|---|---|---|---|
Partition coefficient of TB (blood to water) | λ _{TB, bld} |
Loguniform (1, 1.0E+3) | Assumed | 7.47 | 7.47 | (5.96, 8.93) |
Dissociation constant of E_{2} binding to ER in brain (nmol/L) | K _{d_E2ER, brn} |
Lognormal (8.6, 3) | Denny et al. [15] | 1.12 | 1.08 | (0.71, 1.87) |
Relative binding affinity of EE_{2} to E_{2} for ER binding | RBA_{EE2_E2} |
Lognormal (1.66, 3) |
Denny et al. [15] Gale et al. [14] | 3.24 | 1.64 | (0.030, 16.79) |
Relative binding affinity of TB to T for AR binding | RBA_{TB_T} |
Lognormal (6.03, 3) | Wilson et al. [64] | 5.25 | 4.84 | (2.29, 10.76) |
Inhibition factor for LH production by bound AR (nmol/L) | ρ _{d_LH, brn} |
LogUniform (0.01, 1.0E+3) | Assumed | 0.11 | 0.10 | (0.042, 0.21) |
Induction factor for LH production by bound ER (nmol/L) | ρ_{u}__{LH, brn} |
LogUniform (0.01, 1.0E+3) | Assumed | 238 | 138 | (4.23, 864) |
Hill coefficient for T production | n _{T} |
Lognormal (1.8, 3) | Murphy et al. [63] | 1.03 | 1.01 | (0.93, 1.19) |
Proportionality constant relating cholesterol to StAR | ρ _{Chol, gon} |
Loguniform (1, 5.0E+3) | Artemenk et al. [70] | 2.37 | 1.83 | (1.04, 6.69) |
Scaling coefficient of Vmax for E_{2} production in gonad (nmol/hr/mg micro-protein) | sc_Vmax_{aro, gon} |
Loguniform (2.3E-5, 0.23) | Zhao et al. [71] | 1.56E-3 | 1.53E-3 | (1.15E-3, 2.12E-3) |
Induction factor of E_{2} production by bound LH (L/nmol) | ρ _{E2_LHLR, gon} |
Loguniform (0.1, 100) | assumed | 79.84 | 82.79 | (42.61, 99.15) |
Scaling coefficient of Vmax for Vtg production in liver (= Vmax/BodyWeight^{0.75}) (nmol/hr/kg^{0.75}) | sc_Vmax_{Vtg, liv} |
Loguniform (1, 1.0E+4) | Watanabe et al. [20] | 175 | 169 | (121, 271) |
Hill coefficient of Vtg production in liver | n _{VTG} |
Uniform (1, 10) | Assumed | 2.88 | 2.87 | (1.97, 3.87) |
ER background production rate in liver (nmol/L/hr) | Pbg_{ER, liv} |
Loguniform (5.0E-5, 0.5) | assumed | 0.12 | 0.12 | (0.084, 0.17) |
Induction rate constant for ER production in liver (1/hr) | k_{ER, liv} |
Lognormal (0.08, 3) | Watanabe et al. [20] | 0.027 | 0.025 | (5.73E-3, 0.065) |
AR background production rate in brain (nmol/L/hr) | Pbg_{AR, brn} |
Loguniform (5.0E-5, 0.5) | assumed | 0.012 | 0.012 | (9.1E-3, 0.015) |
Inhibition factor of AR production by free androgens (nmol/L) | K_{AR, brn} |
Loguniform (5E-4, 5) | assumed | 3.95 | 4.08 | (2.15, 4.95) |
Magnitude of LH production (nmol/hr) | Mag_{LH} |
Loguniform (2.7E-7, 2.7E-3) | Schulz et al. [72] | 8.86E-6 | 8.75E-6 | (6.29E-6, 1.20E-5) |
Error variance of plasma E_{2} concentration in natural log space for unexposed female FHMs | Var_Ln_CE2tot_pla_ngml |
Inverse Gamma (2, 1.19) | Bois et al. [73] | 0.52 | 0.51 | (0.38, 0.73) |
Error variance of plasma T concentration in natural log space for unexposed female FHMs | Var_Ln_CTtot_pla_ngml |
Inverse Gamma (2, 0.53) | Bois et al. [73] | 0.48 | 0.47 | (0.34, 0.69) |
Error variance of plasma VTG concentration in natural log space for unexposed female FHMs | Var_Ln_CVTG_pla_mgml |
Inverse Gamma (2, 5.31) | Bois et al. [73] | 0.49 | 0.48 | (0.35, 0.68) |
Error variance of plasma E_{2} concentration in natural log space for TB-exposed female FHMs | Var_Ln_CE2tot_pla_ngml |
Inverse Gamma (2, 1.19) | Bois et al. [73] | 0.70 | 0.69 | (0.48, 1.03) |
Error variance of plasma T concentration in natural log space for TB-exposed female FHMs | Var_Ln_CTtot_pla_ngml |
Inverse Gamma (2, 0.53) | Bois et al. [73] | 0.40 | 0.39 | (0.27, 0.60) |
Error variance of plasma VTG concentration in natural log space for TB-exposed female FHMs | Var_Ln_CVTG_pla_mgml |
Inverse Gamma (2, 5.31) | Bois et al. [73] | 5.86 | 5.72 | (3.98, 8.60) |
Error variance of plasma E_{2} concentration in natural log space for EE_{2}-exposed female FHMs | Var_Ln_CE2tot_pla_ngml |
Inverse Gamma (2, 1.19) | Bois et al. [73] | 1.43 | 0.81 | (0.22, 6.31) |
Error variance of plasma T concentration in natural log space for EE_{2}-exposed female FHMs | Var_Ln_CTtot_pla_ngml |
Inverse Gamma (2, 0.53) | Bois et al. [73] | 0.59 | 0.34 | (0.10, 2.76) |
Error variance of plasma VTG concentration in natural log space for EE_{2}-exposed female FHMs | Var_Ln_CVTG_pla_mgml |
Inverse Gamma (2, 5.31) | Bois et al. [73] | 0.73 | 0.71 | (0.51, 1.03) |